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S

SagCAD  (2D CAD - GPL)
Sailcut CAD  (3D CAD - sail design and plotting software, GPL)
ScriptCAD  (2D CAD)
SeaSolution  (3D CAD - marine industry)
Shape CAD  (Architectural Pocket 3D CAD)
SharpConstruct  (modeler - GPL)
Silo
(
3D modeling application with the ability to effortlessly switch between organically sculpting high-polygon models and precisely controlling hard-edged surfaces.)
SketchUp  (3D CAD)
SoftCAD 3D  (3D CAD)
Solid Edge  (3D CAD)
SolidWorks  (3D CAD)
Spirit  (3D CAD)
Strata 3D  (complete 3D)
Stratis  (3D CAD - drive-way...)
Surface Evolver
(
modelling of liquid surfaces shaped by various forces and constraints)
Sweet Home 3D
(...
is a free interior design application that helps you placing your furniture
on a house 2D plan, with a 3D preview
- GPL)